DNA technology is going through evolution every passing day. With the recent advancements in DNA testing, the process has improved for the better. Getting a NIPP test done on time, before the baby is born, is lifesaving for couples going through an infidelity crisis. It provides them with a sense of peace and clarity. It gives them the opportunity to widen their perspective and make important decisions for the better.
The invasive prenatal pregnancy tests were risky and uncomfortable, with greater risks for a miscarriage or complications in a baby. Through the introduction of non invasive prenatal paternity tests, DNA testing and paternity testing has become far more easier and safer. Couples now prefer this method since it is convenient and affordable as well. As a mother, with NIPP testing, you can accurately find out who the father of the child is and save yourself of the financial burden of taking care of the baby on your own.
What Is NIPP Testing?
Non-invasive prenatal test is a scientific method of determining the father of a baby through DNA testing method. NIPP testing can be done as early as 7th week into pregnancy, providing you with a sense of relief and showing you a path to select. With NIPP testing, you can choose a direction and plan on whether to associate yourself to the baby or not.
What are cfDNA Fragments?
When a mother is pregnant, her blood stream may contain fragments of a material called the cfDNA. This is the fetal DNA framents found within her blood. These cfDNA fragments are formed through the breakdown products or cell death. It then enters the blood streams and moves around for a while before it disintegrates forever. The cfDNA fragments are fetal DNA that contains all information about the unborn baby and can help in the detection of anomalies.
Process of Detection Extraction of Fetal DNA:
The process of detecting extracting DNA structure of the fetus is quite simple. Given below is the procedure of extraction of the fetal DNA:
- A sample of the mother’s blood is taken and stored properly in air tight containers and sent forward for extracting the DNA structure.
- The amount of cfDNA made available during extraction through the mother’s blood is called Fetal Fraction
- The fetal fraction is then useful to use in the NIPT test.
- The DNA is then analyzed and examined for any abnormalities or anomalies.
Determining Chromosomal Disorders:
The fetal fraction in NIPT test is extremely useful in finding out chromosomal abnormalities before birth. These chromosomal abnormalities or disorders often have an extra or a missing chromosome. With the help of a NIPT test, couples can find out abnormalities within their child before they are born. This gives them the opportunity to take the right step and decide whether to keep the baby or abort it. Some of the diseases discovered through a NIPT test are:
- Down Syndrome ( Trisomy 21 )
- Patau Syndrome ( Trisomy 13 )
- Kleinfelter Syndrome ( affecting X and Y chromosome )
- Turner Syndrome ( affecting X and Y chromosome )
- Edwards Syndrome ( Trisomy 18 )
NIPT can also help determine the gender of your baby. Hence, making it easier for couples to find out the sex of the baby in the starting days of pregnancy. This means there is no need to wait for 5 months to find out the gender of the baby via ultrasound.
Fetal Fraction:
Fetal fraction as learnt, is the amount of cfDNA present within the blood streams of the mother. It is extracted and purified from the cfDNA of the mother and rest of the cells. The amount of fetal DNA fraction present will help determine the accuracy of your test. The minimum amount of fetal fraction required to accurately carry out a NIPT is about 4 percent. Anything less than this will lead to a false negative. The amount of fetal DNA fraction may sometimes be disturbed due to reasons like, maternal weight, gestational age, etc.
Accuracy Of The Test:
Although the NIPT test is quite accurate, there may be changes within the results. Sometimes, the test can give a false positive or a false negative. It all depends on the amount of fetal DNA fraction present within the blood streams. And since, both the mother and baby’s DNA are used, it can help discover disorders that were never present or expressed within the mother.
Summary:
To summarize, the NIPT NIPP tests are excellent testing methods for determining abnormalities and paternity respectively. Hence, it is important to choose the best available testing lab that is accredited and experienced in such type of testing. "https://facednatest.com/">Face DNA is a top notch testing company that provides accurate and reliable NIPT NIPP testing results.
