QuickBooks Error H101 typically arises when trying to access company files located on another computer, and the system needs additional configuration for proper connectivity. This error indicates that the computer on which the QuickBooks company file is stored requires additional setup to allow sharing of files and data. To resolve this, users can adjust their hosting settings, configure their firewall software to allow exceptions for QuickBooks or use the QuickBooks Error code H101 File Doctor Tool to diagnose and repair network issues related to this error.